5WBU
Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex
Summary for 5WBU
Entry DOI | 10.2210/pdb5wbu/pdb |
Descriptor | Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1 (3 entities in total) |
Functional Keywords | complex, frb, wd40, pras40, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P42345 Cytoplasm : Q9BVC4 Cytoplasm, cytosol : Q96B36 |
Total number of polymer chains | 8 |
Total formula weight | 381231.46 |
Authors | Pavletich, N.P.,Yang, H. (deposition date: 2017-06-29, release date: 2017-12-20, Last modification date: 2023-10-04) |
Primary citation | Yang, H.,Jiang, X.,Li, B.,Yang, H.J.,Miller, M.,Yang, A.,Dhar, A.,Pavletich, N.P. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552:368-373, 2017 Cited by PubMed: 29236692DOI: 10.1038/nature25023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.42 Å) |
Structure validation
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