5W41

Zika MR766 NLS in complex with Importin alpha subunit-1

Summary for 5W41

• Entry DOI: 10.2210/pdb5w41/pdb
• Descriptor: Importin subunit alpha-1, ZIKA MR766 NLS (3 entities in total)
• Functional Keywords: zika, nuclear transport, importin, karyopherin, virus, mr766, viral protein-protein binding complex, viral protein/protein binding
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 59940.96

Authors

Jeffress, S.,Smith, K.M.,Forwood, J.K. (deposition date: 2017-06-08, release date: 2018-06-13, Last modification date: 2023-10-04)

• Primary citation: Ng, I.H.W.,Chan, K.,Tan, M.J.A.,Gwee, C.P.,Smith, K.M.,Jeffress, S.J.,Saw, W.G.,Swarbrick, C.M.D.,Watanabe, S.,Jans, D.,Gruber, G.,Forwood, J.K.,Vasudevan, S.G.; Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells.; ACS Infect Dis, 2019; PubMed: 30848123; DOI: 10.1021/acsinfecdis.8b00373

Experimental method

X-RAY DIFFRACTION (2.2 Å)