5W2I

Crystal structure of the core catalytic domain of human inositol phosphate multikinase soaked with C4-analogue of PtdIns(4,5)P2 and ADP

Summary for 5W2I

• Entry DOI: 10.2210/pdb5w2i/pdb
• Related: 5W2G 5W2H
• Descriptor: Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: kinase, inositol, inositol polyphosphate, phosphatidylinositol, specificity, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q8NFU5
• Total number of polymer chains: 1
• Total formula weight: 30323.37

Authors

Wang, H.,Shears, S.B. (deposition date: 2017-06-06, release date: 2017-09-13, Last modification date: 2024-03-13)

• Primary citation: Wang, H.,Shears, S.B.; Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.; J. Biol. Chem., 292:18192-18202, 2017; PubMed: 28882892; DOI: 10.1074/jbc.M117.801845

Experimental method

X-RAY DIFFRACTION (1.6 Å)