5W0C
Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex
Summary for 5W0C
Entry DOI | 10.2210/pdb5w0c/pdb |
Descriptor | Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, ethyl {2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamate, ... (5 entities in total) |
Functional Keywords | inhibitor complex, p450 monooxygenase, cytochrome p450 2c9, cyp2c9, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 55407.88 |
Authors | Johnson, E.F.,Hsu, M.-H. (deposition date: 2017-05-30, release date: 2017-09-13, Last modification date: 2023-10-04) |
Primary citation | Liu, R.,Lyu, X.,Batt, S.M.,Hsu, M.H.,Harbut, M.B.,Vilcheze, C.,Cheng, B.,Ajayi, K.,Yang, B.,Yang, Y.,Guo, H.,Lin, C.,Gan, F.,Wang, C.,Franzblau, S.G.,Jacobs, W.R.,Besra, G.S.,Johnson, E.F.,Petrassi, M.,Chatterjee, A.K.,Futterer, K.,Wang, F. Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angew. Chem. Int. Ed. Engl., 56:13011-13015, 2017 Cited by PubMed: 28815830DOI: 10.1002/anie.201707324 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
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