5VT1

Crystal Structure of the Human CAMKK2B bound to a thiadiazinone benzamide inhibitor

Summary for 5VT1

Entry DOI	10.2210/pdb5vt1/pdb
Descriptor	Calcium/calmodulin-dependent protein kinase kinase 2, 4-({5-[(3-hydroxy-4-methylphenyl)amino]-4-oxo-4H-1,2,6-thiadiazin-3-yl}amino)benzamide, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33520.95
Authors	Counago, R.M.,Asquith, C.R.M.,Arruda, P.,Edwards, A.M.,Gileadi, O.,Kalogirou, A.S.,Koutentis, P.A.,Structural Genomics Consortium (SGC) (deposition date: 2017-05-15, release date: 2017-05-24, Last modification date: 2023-10-04)
Primary citation	Asquith, C.R.M.,Godoi, P.H.,Counago, R.M.,Laitinen, T.,Scott, J.W.,Langendorf, C.G.,Oakhill, J.S.,Drewry, D.H.,Zuercher, W.J.,Koutentis, P.A.,Willson, T.M.,Kalogirou, A.S. 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors. Molecules, 23:-, 2018 Cited by PubMed: 29783765 DOI: 10.3390/molecules23051221 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation