5VSE
Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
Summary for 5VSE
Entry DOI | 10.2210/pdb5vse/pdb |
Descriptor | Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total) |
Functional Keywords | protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65561.07 |
Authors | Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2017-05-11, release date: 2017-07-19, Last modification date: 2023-10-04) |
Primary citation | Xiong, Y.,Li, F.,Babault, N.,Wu, H.,Dong, A.,Zeng, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg. Med. Chem., 25:4414-4423, 2017 Cited by PubMed: 28662962DOI: 10.1016/j.bmc.2017.06.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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