5VME
Crystal structure of human IgG1 Fc K248E, T437R mutant
Summary for 5VME
Entry DOI | 10.2210/pdb5vme/pdb |
Descriptor | human IgG1 Fc K248E,T437R mutant, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | fc, immunoglobulin fold, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 53094.55 |
Authors | Armstrong, A.A.,Gilliland, G.L. (deposition date: 2017-04-27, release date: 2017-08-30, Last modification date: 2023-10-04) |
Primary citation | Zhang, D.,Armstrong, A.A.,Tam, S.H.,McCarthy, S.G.,Luo, J.,Gilliland, G.L.,Chiu, M.L. Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization. MAbs, 9:1129-1142, 2017 Cited by PubMed: 28758875DOI: 10.1080/19420862.2017.1358838 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
Download full validation report