5VI9

Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitors

Summary for 5VI9

Entry DOI	10.2210/pdb5vi9/pdb
Related	5VHB 5VIB
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, PKI peptide, N-[(3-fluorophenyl)methyl]-6-(pyridin-4-yl)-1,3-benzothiazol-2-amine, ... (4 entities in total)
Functional Keywords	kinase, transferase
Biological source	Bos taurus (Bovine) More
Cellular location	Cytoplasm : P00517
Total number of polymer chains	2
Total formula weight	43066.21
Authors	Judge, R.A. (deposition date: 2017-04-14, release date: 2018-01-31, Last modification date: 2018-04-04)
Primary citation	Judge, R.A.,Vasudevan, A.,Scott, V.E.,Simler, G.H.,Pratt, S.D.,Namovic, M.T.,Putman, C.B.,Aguirre, A.,Stoll, V.S.,Mamo, M.,Swann, S.I.,Cassar, S.C.,Faltynek, C.R.,Kage, K.L.,Boyce-Rustay, J.M.,Hobson, A.D. Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate. Chembiochem, 19:613-621, 2018 Cited by PubMed: 29314498 DOI: 10.1002/cbic.201700547 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation