5VBE

Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GDP

Summary for 5VBE

• Entry DOI: 10.2210/pdb5vbe/pdb
• Related: 5VBM
• Descriptor: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, ... (5 entities in total)
• Functional Keywords: gtpase, inhibitor, gdp, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 20077.47

Authors

Gentile, D.R.,Jenkins, M.L.,Moss, S.M.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-29, release date: 2017-10-25, Last modification date: 2023-10-04)

• Primary citation: Gentile, D.R.,Rathinaswamy, M.K.,Jenkins, M.L.,Moss, S.M.,Siempelkamp, B.D.,Renslo, A.R.,Burke, J.E.,Shokat, K.M.; Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.; Cell Chem Biol, 24:1455-1466.e14, 2017; PubMed: 29033317; DOI: 10.1016/j.chembiol.2017.08.025

Experimental method

X-RAY DIFFRACTION (1.57 Å)