5VAQ

Crystal Structure of Beta-Klotho in Complex with FGF21CT

Summary for 5VAQ

• Entry DOI: 10.2210/pdb5vaq/pdb
• Related: 5V9Q 5V9R
• Descriptor: Beta-klotho, Nb914, Fibroblast growth factor 21, ... (4 entities in total)
• Functional Keywords: (beta/alpha) 8 receptor for endocrine fgf, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 127050.57

Authors

Lee, S.,Schlessinger, J. (deposition date: 2017-03-27, release date: 2018-01-31, Last modification date: 2021-03-24)

• Primary citation: Lee, S.,Choi, J.,Mohanty, J.,Sousa, L.P.,Tome, F.,Pardon, E.,Steyaert, J.,Lemmon, M.A.,Lax, I.,Schlessinger, J.; Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.; Nature, 553:501-505, 2018; PubMed: 29342135; DOI: 10.1038/nature25010

Experimental method

X-RAY DIFFRACTION (2.606 Å)