5V7W

Crystal structure of human PARP14 bound to 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one inhibitor

Summary for 5V7W

• Entry DOI: 10.2210/pdb5v7w/pdb
• Related: 5V7T
• Descriptor: Poly [ADP-ribose] polymerase 14, 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one (3 entities in total)
• Functional Keywords: human parp14, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 44867.92

Authors

saikatendu, k.s.,Hirozane, M. (deposition date: 2017-03-20, release date: 2017-05-10, Last modification date: 2018-11-14)

• Primary citation: Yoneyama-Hirozane, M.,Matsumoto, S.I.,Toyoda, Y.,Saikatendu, K.S.,Zama, Y.,Yonemori, K.,Oonishi, M.,Ishii, T.,Kawamoto, T.; Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.; Biochem. Biophys. Res. Commun., 486:626-631, 2017; PubMed: 28315326; DOI: 10.1016/j.bbrc.2017.03.052

Experimental method

X-RAY DIFFRACTION (2.65 Å)