5V6A

Crystal structure of the Middle East respiratory syndrome coronavirus papain-like protease bound to ubiquitin variant ME.2

Summary for 5V6A

• Entry DOI: 10.2210/pdb5v6a/pdb
• Related: 5V69
• Descriptor: MERS-CoV PLpro, ME.2, ZINC ION, ... (6 entities in total)
• Functional Keywords: plpro, ubiquitin variant, dub, hydrolase
• Biological source: Human betacoronavirus 2c EMC/2012; More
• Total number of polymer chains: 2
• Total formula weight: 48921.82

Authors

Bailey-Elkin, B.A.,Mark, B.L. (deposition date: 2017-03-16, release date: 2017-05-10, Last modification date: 2024-03-06)

• Primary citation: Zhang, W.,Bailey-Elkin, B.A.,Knaap, R.C.M.,Khare, B.,Dalebout, T.J.,Johnson, G.G.,van Kasteren, P.B.,McLeish, N.J.,Gu, J.,He, W.,Kikkert, M.,Mark, B.L.,Sidhu, S.S.; Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.; PLoS Pathog., 13:e1006372-e1006372, 2017; PubMed: 28542609; DOI: 10.1371/journal.ppat.1006372

Experimental method

X-RAY DIFFRACTION (2.7 Å)