5V3Q

Human GSTO1-1 complexed with ML175

Summary for 5V3Q

• Entry DOI: 10.2210/pdb5v3q/pdb
• Related: 1EEM 3VLN 4IS0
• Descriptor: Glutathione S-transferase omega-1, N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: glutathione transferase, inhibitor, ml175, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol : P78417
• Total number of polymer chains: 1
• Total formula weight: 28159.68

Authors

Oakley, A.J. (deposition date: 2017-03-07, release date: 2017-12-20, Last modification date: 2023-10-04)

• Primary citation: Menon, D.,Innes, A.,Oakley, A.J.,Dahlstrom, J.E.,Jensen, L.M.,Brustle, A.,Tummala, P.,Rooke, M.,Casarotto, M.G.,Baell, J.B.,Nguyen, N.,Xie, Y.,Cuellar, M.,Strasser, J.,Dahlin, J.L.,Walters, M.A.,Burgio, G.,O'Neill, L.A.J.,Board, P.G.; GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.; Sci Rep, 7:17832-17832, 2017; PubMed: 29259211; DOI: 10.1038/s41598-017-17861-6

Experimental method

X-RAY DIFFRACTION (2.25 Å)