5V18

Structure of PHD2 in complex with 1,2,4-Triazolo-[1,5-a]pyridine

Summary for 5V18

• Entry DOI: 10.2210/pdb5v18/pdb
• Related: 5V1B
• Descriptor: Egl nine homolog 1, SULFATE ION, 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile, ... (5 entities in total)
• Functional Keywords: hif prolylhydroxylase domain-2, inhibitor, momodentate binding, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q9GZT9
• Total number of polymer chains: 1
• Total formula weight: 27161.58

Authors

Skene, R.J. (deposition date: 2017-03-01, release date: 2017-06-21, Last modification date: 2024-03-06)

• Primary citation: Ahmed, S.,Ayscough, A.,Barker, G.R.,Canning, H.E.,Davenport, R.,Downham, R.,Harrison, D.,Jenkins, K.,Kinsella, N.,Livermore, D.G.,Wright, S.,Ivetac, A.D.,Skene, R.,Wilkens, S.J.,Webster, N.A.,Hendrick, A.G.; 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.; J. Med. Chem., 60:5663-5672, 2017; PubMed: 28594552; DOI: 10.1021/acs.jmedchem.7b00352

Experimental method

X-RAY DIFFRACTION (2.15 Å)