5UWD

Crystal structure of EGFR kinase domain (L858R, T790M, V948R) in complex with the covalent inhibitor CO-1686

Summary for 5UWD

Entry DOI	10.2210/pdb5uwd/pdb
Related	5UGC
Descriptor	Epidermal growth factor receptor, N-(3-{[2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)propanamide (2 entities in total)
Functional Keywords	egfr, kinase, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38138.02
Authors	Gajiwala, K.S.,Ferre, R.A. (deposition date: 2017-02-21, release date: 2017-10-18, Last modification date: 2017-11-29)
Primary citation	Niessen, S.,Dix, M.M.,Barbas, S.,Potter, Z.E.,Lu, S.,Brodsky, O.,Planken, S.,Behenna, D.,Almaden, C.,Gajiwala, K.S.,Ryan, K.,Ferre, R.,Lazear, M.R.,Hayward, M.M.,Kath, J.C.,Cravatt, B.F. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. Cell Chem Biol, 24:1388-1400.e7, 2017 Cited by PubMed: 28965727 DOI: 10.1016/j.chembiol.2017.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.06 Å)

Structure validation