5UV5
Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
Summary for 5UV5
Entry DOI | 10.2210/pdb5uv5/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | reverse transcriptase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 4 |
Total formula weight | 229110.14 |
Authors | Kirby, K.A.,Sarafianos, S.G. (deposition date: 2017-02-19, release date: 2017-08-16, Last modification date: 2023-10-04) |
Primary citation | Kirby, K.A.,Myshakina, N.A.,Christen, M.T.,Chen, Y.L.,Schmidt, H.A.,Huber, A.D.,Xi, Z.,Kim, S.,Rao, R.K.,Kramer, S.T.,Yang, Q.,Singh, K.,Parniak, M.A.,Wang, Z.,Ishima, R.,Sarafianos, S.G. A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase. Antimicrob. Agents Chemother., 61:-, 2017 Cited by PubMed: 28760905DOI: 10.1128/AAC.01351-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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