5USJ
Crystal Structure of human KRAS G12D mutant in complex with GDPNP
Summary for 5USJ
Entry DOI | 10.2210/pdb5usj/pdb |
Related | 5UQW 5US4 |
Descriptor | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total) |
Functional Keywords | kras, gtpase, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 6 |
Total formula weight | 132285.99 |
Authors | Huang, C.S.,Kaplan, A.,Stockwell, B.R.,Tong, L. (deposition date: 2017-02-13, release date: 2017-03-22, Last modification date: 2024-03-06) |
Primary citation | Welsch, M.E.,Kaplan, A.,Chambers, J.M.,Stokes, M.E.,Bos, P.H.,Zask, A.,Zhang, Y.,Sanchez-Martin, M.,Badgley, M.A.,Huang, C.S.,Tran, T.H.,Akkiraju, H.,Brown, L.M.,Nandakumar, R.,Cremers, S.,Yang, W.S.,Tong, L.,Olive, K.P.,Ferrando, A.,Stockwell, B.R. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell, 168:878-889.e29, 2017 Cited by PubMed: 28235199DOI: 10.1016/j.cell.2017.02.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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