5URM

Crystal structure of human BRR2 in complex with T-1206548

Summary for 5URM

• Entry DOI: 10.2210/pdb5urm/pdb
• Related: 5URJ 5URK
• Descriptor: U5 small nuclear ribonucleoprotein 200 kDa helicase, 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid (3 entities in total)
• Functional Keywords: brr2 inhibitor, rna helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : O75643
• Total number of polymer chains: 2
• Total formula weight: 398070.18

Authors

Klein, M.G.,Tjhen, R.,Qin, L. (deposition date: 2017-02-11, release date: 2017-07-19, Last modification date: 2024-03-06)

• Primary citation: Iwatani-Yoshihara, M.,Ito, M.,Klein, M.G.,Yamamoto, T.,Yonemori, K.,Tanaka, T.,Miwa, M.,Morishita, D.,Endo, S.,Tjhen, R.,Qin, L.,Nakanishi, A.,Maezaki, H.,Kawamoto, T.; Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.; J. Med. Chem., 60:5759-5771, 2017; PubMed: 28586220; DOI: 10.1021/acs.jmedchem.7b00461

Experimental method

X-RAY DIFFRACTION (2.8 Å)