5UI0

Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation

Summary for 5UI0

Entry DOI	10.2210/pdb5ui0/pdb
Related	5UGL 5UGX 5UHN
Descriptor	Fibroblast growth factor receptor 2, CITRATE ANION, SULFATE ION, ... (5 entities in total)
Functional Keywords	tyrosine kinase domain, gain-of-function mutation, atp analog cell surface receptor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	75088.59
Authors	Mohammadi, M.,Chen, H. (deposition date: 2017-01-12, release date: 2017-02-22, Last modification date: 2023-10-04)
Primary citation	Chen, H.,Marsiglia, W.M.,Cho, M.K.,Huang, Z.,Deng, J.,Blais, S.P.,Gai, W.,Bhattacharya, S.,Neubert, T.A.,Traaseth, N.J.,Mohammadi, M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife, 6:-, 2017 Cited by PubMed: 28166054 DOI: 10.7554/eLife.21137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation