5UGL

Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation

Summary for 5UGL

Entry DOI	10.2210/pdb5ugl/pdb
Related	5UGX 5UHN 5UI0
Descriptor	Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	tyrosine kinase domain, atp analoge, gain-of-function mutation, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	75393.77
Authors	Mohammadi, M.,Chen, H. (deposition date: 2017-01-09, release date: 2017-02-22, Last modification date: 2023-10-04)
Primary citation	Chen, H.,Marsiglia, W.M.,Cho, M.K.,Huang, Z.,Deng, J.,Blais, S.P.,Gai, W.,Bhattacharya, S.,Neubert, T.A.,Traaseth, N.J.,Mohammadi, M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife, 6:-, 2017 Cited by PubMed: 28166054 DOI: 10.7554/eLife.21137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.861 Å)

Structure validation