5UHO
Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with PUGNAc
Summary for 5UHO
Entry DOI | 10.2210/pdb5uho/pdb |
Related | 5UHK 5UHL 5UHP |
Descriptor | O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, ... (4 entities in total) |
Functional Keywords | hydrolase, o-glcnacase, gh84, enzyme, pugnac |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502 O60502 |
Total number of polymer chains | 4 |
Total formula weight | 118254.49 |
Authors | Klein, D.J.,Elsen, N.L. (deposition date: 2017-01-11, release date: 2017-03-29, Last modification date: 2024-03-06) |
Primary citation | Elsen, N.L.,Patel, S.B.,Ford, R.E.,Hall, D.L.,Hess, F.,Kandula, H.,Kornienko, M.,Lumb, K.J.,Reid, J.,Selnick, H.,Shipman, J.M.,Sharma, S.,Soisson, S.M.,Klein, D.J. Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.21 Å) |
Structure validation
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