5U94
Crystal structure of the Mycobacterium tuberculosis PASTA kinase PknB in complex with the potential theraputic kinase inhibitor GSK690693.
Summary for 5U94
| Entry DOI | 10.2210/pdb5u94/pdb |
| Descriptor | Serine/threonine-protein kinase PknB, 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3 -yn-2-ol, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 1 |
| Total formula weight | 32014.26 |
| Authors | Wlodarchak, N.,Satyshur, K.,Striker, R. (deposition date: 2016-12-15, release date: 2017-12-20, Last modification date: 2023-10-04) |
| Primary citation | Wlodarchak, N.,Teachout, N.,Beczkiewicz, J.,Procknow, R.,Schaenzer, A.J.,Satyshur, K.,Pavelka, M.,Zuercher, W.,Drewry, D.,Sauer, J.D.,Striker, R. In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with beta-Lactams To Inhibit Mycobacterial Growth. Mol. Pharm., 15:5410-5426, 2018 Cited by PubMed: 30285456DOI: 10.1021/acs.molpharmaceut.8b00905 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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