5TUI

Crystal structure of tetracycline destructase Tet(50) in complex with chlortetracycline

Summary for 5TUI

Entry DOI	10.2210/pdb5tui/pdb
Related	5TUE 5TUF 5TUK 5TUL 5TUM
Descriptor	Tetracycline destructase Tet(50), SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	fad-binding, tetracycline-inactivating, oxidoreductase activity, oxidoreductase
Biological source	uncultured bacterium
Total number of polymer chains	2
Total formula weight	94590.80
Authors	Park, J.,Tolia, N.H. (deposition date: 2016-11-06, release date: 2017-05-10, Last modification date: 2024-03-06)
Primary citation	Park, J.,Gasparrini, A.J.,Reck, M.R.,Symister, C.T.,Elliott, J.L.,Vogel, J.P.,Wencewicz, T.A.,Dantas, G.,Tolia, N.H. Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes. Nat. Chem. Biol., 13:730-736, 2017 Cited by PubMed: 28481346 DOI: 10.1038/nchembio.2376 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation