5TQG
Factor VIIa in complex with the inhibitor (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione
Summary for 5TQG
Entry DOI | 10.2210/pdb5tqg/pdb |
Related | 5TQE 5TQF |
Descriptor | Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione, ... (7 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35608.51 |
Authors | |
Primary citation | Richter, J.M.,Cheney, D.L.,Bates, J.A.,Wei, A.,Luettgen, J.M.,Rendina, A.R.,Harper, T.M.,Narayanan, R.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S. Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Med Chem Lett, 8:67-72, 2017 Cited by PubMed: 28105277DOI: 10.1021/acsmedchemlett.6b00375 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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