5TQ8
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Summary for 5TQ8
Entry DOI | 10.2210/pdb5tq8/pdb |
Related | 5TQ3 5TQ4 5TQ5 5TQ6 5TQ7 5TQ8 |
Descriptor | Tyrosine-protein kinase JAK2, {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone (3 entities in total) |
Functional Keywords | kinase, inflammation, jak inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 1 |
Total formula weight | 35440.36 |
Authors | Chrencik, J.,Jones, P. (deposition date: 2016-10-23, release date: 2017-01-11, Last modification date: 2023-10-04) |
Primary citation | Jones, P.,Storer, R.I.,Sabnis, Y.A.,Wakenhut, F.M.,Whitlock, G.A.,England, K.S.,Mukaiyama, T.,Dehnhardt, C.M.,Coe, J.W.,Kortum, S.W.,Chrencik, J.E.,Brown, D.G.,Jones, R.M.,Murphy, J.R.,Yeoh, T.,Morgan, P.,Kilty, I. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J. Med. Chem., 60:767-786, 2017 Cited by PubMed: 27983835DOI: 10.1021/acs.jmedchem.6b01634 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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