5TOP

Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 S70G Beta-Lactamase

Summary for 5TOP

Entry DOI	10.2210/pdb5top/pdb
Descriptor	Beta-lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[carboxy(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (7 entities in total)
Functional Keywords	beta-lactamase, organometallic, ruthenocene, ctx-m-14, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	58135.18
Authors	Lewandowski, E.M.,Chen, Y. (deposition date: 2016-10-18, release date: 2017-11-08, Last modification date: 2023-10-04)
Primary citation	Lewandowski, E.M.,Lethbridge, K.G.,Sanishvili, R.,Skiba, J.,Kowalski, K.,Chen, Y. Mechanisms of proton relay and product release by Class A beta-lactamase at ultrahigh resolution. FEBS J., 285:87-100, 2018 Cited by PubMed: 29095570 DOI: 10.1111/febs.14315 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.18 Å)

Structure validation