5TNG
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EpETE hydrolysis intermediate
Summary for 5TNG
| Entry DOI | 10.2210/pdb5tng/pdb |
| Related | 3KD2 4DMC |
| Descriptor | CFTR inhibitory factor, (5Z,8Z,11Z,14R,15R,17Z)-14,15-dihydroxyicosa-5,8,11,17-tetraenoic acid (3 entities in total) |
| Functional Keywords | epoxide hydrolase, hydroxyalkyl-enzyme intermediate, hydrolase |
| Biological source | Pseudomonas aeruginosa (strain UCBPP-PA14) |
| Total number of polymer chains | 4 |
| Total formula weight | 138000.72 |
| Authors | Hvorecny, K.L.,Madden, D.R. (deposition date: 2016-10-14, release date: 2017-10-11, Last modification date: 2023-10-04) |
| Primary citation | Hvorecny, K.L.,Bahl, C.D.,Kitamura, S.,Lee, K.S.S.,Hammock, B.D.,Morisseau, C.,Madden, D.R. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure, 25:697-707.e4, 2017 Cited by PubMed: 28392259DOI: 10.1016/j.str.2017.03.002 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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