5TMS
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Cyclofenil-ASC derivative, ethyl (E)-3-(4-(bicyclo[3.3.1]nonan-9-ylidene(4-hydroxyphenyl)methyl)phenyl)acrylate
Summary for 5TMS
Entry DOI | 10.2210/pdb5tms/pdb |
Related | 5TMR 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, ethyl 3-(4-{[(1s,5s)-bicyclo[3.3.1]nonan-9-ylidene](4-hydroxyphenyl)methyl}phenyl)prop-2-enoate, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 62563.85 |
Authors | Nwachukwu, J.C.,Erumbi, R.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Izard, T.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-10-13, release date: 2017-01-18, Last modification date: 2024-03-06) |
Primary citation | Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24:35-45, 2017 Cited by PubMed: 28042045DOI: 10.1016/j.chembiol.2016.11.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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