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5TMZ

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S,17S)-16-(3-methoxybenzyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Summary for 5TMZ
Entry DOI10.2210/pdb5tmz/pdb
Related5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, (9beta,13alpha,14beta,16alpha,17alpha)-16-[(4-methoxyphenyl)methyl]estra-1,3,5(10)-triene-3,17-diol, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Nucleus: Q15596
Total number of polymer chains4
Total formula weight62543.86
Authors
Nwachukwu, J.C.,Erumbi, R.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Izard, T.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-10-13, release date: 2017-01-18, Last modification date: 2024-03-06)
Primary citationNwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W.
Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24:35-45, 2017
Cited by
PubMed: 28042045
DOI: 10.1016/j.chembiol.2016.11.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.207 Å)
Structure validation

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