5TI9

Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161

Summary for 5TI9

Entry DOI	10.2210/pdb5ti9/pdb
Related	5TIA
Descriptor	Tryptophan 2,3-dioxygenase, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	human tryptophan 2, 3-dioxygenase in complex with trp and o2, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	185147.83
Authors	Forouhar, F.,Lewis-Ballester, A.,Lew, S.,Karkashon, S.,Seetharaman, J.,Yeh, S.R.,Tong, L. (deposition date: 2016-10-01, release date: 2016-10-26, Last modification date: 2023-11-15)
Primary citation	Lewis-Ballester, A.,Forouhar, F.,Kim, S.M.,Lew, S.,Wang, Y.,Karkashon, S.,Seetharaman, J.,Batabyal, D.,Chiang, B.Y.,Hussain, M.,Correia, M.A.,Yeh, S.R.,Tong, L. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep, 6:35169-35169, 2016 Cited by PubMed: 27762317 DOI: 10.1038/srep35169 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation