5TEH

c-Src V281C kinase domain in complex with Rao-IV-156

Summary for 5TEH

• Entry DOI: 10.2210/pdb5teh/pdb
• Related: 5SWH
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, (2S)-3-[4-amino-7-(2-methoxyethyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanamide (3 entities in total)
• Functional Keywords: ac helix out, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66458.46

Authors

Dieter, E.M.,Merritt, E.A.,Maly, D.J. (deposition date: 2016-09-21, release date: 2017-09-27, Last modification date: 2023-10-04)

• Primary citation: Register, A.C.,Maly, D.J.; A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions; Mol.Cell, 2019:-,

Experimental method

X-RAY DIFFRACTION (2.99 Å)