5TE8
Crystal structure of the midazolam-bound human CYP3A4
Summary for 5TE8
| Entry DOI | 10.2210/pdb5te8/pdb |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, ... (4 entities in total) |
| Functional Keywords | cytochrome p450, cyp3a4, monooxygenase, drug metabolism, midazolam, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 3 |
| Total formula weight | 170100.20 |
| Authors | Sevrioukova, I.,Poulos, T. (deposition date: 2016-09-20, release date: 2016-12-07, Last modification date: 2023-10-04) |
| Primary citation | Sevrioukova, I.F.,Poulos, T.L. Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4. Proc. Natl. Acad. Sci. U.S.A., 114:486-491, 2017 Cited by PubMed: 28031486DOI: 10.1073/pnas.1616198114 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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