5T7O

Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE

Summary for 5T7O

Entry DOI	10.2210/pdb5t7o/pdb
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (6S)-5,6,7,8-TETRAHYDROFOLATE, ... (6 entities in total)
Functional Keywords	oxidoreductase, transferase, folate metabolism, trypanosomatidic infections, trypanosoma cruzi
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	4
Total formula weight	244617.74
Authors	Di Pisa, F.,Dello Iacono, L.,Bonucci, A.,Mangani, S. (deposition date: 2016-09-05, release date: 2017-09-20, Last modification date: 2024-01-17)
Primary citation	Di Pisa, F.,Dello Iacono, L.,Bonucci, A.,Mangani, S. Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE To Be Published,
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation