5T1Z

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Ethoxytriphenylethylene and GRIP Peptide

Replaces:  3Q97

Summary for 5T1Z

• Entry DOI: 10.2210/pdb5t1z/pdb
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, 4,4'-[(1Z)-1-(4-ethoxyphenyl)but-1-ene-1,2-diyl]diphenol, ... (4 entities in total)
• Functional Keywords: estrogen receptor, angular estrogen, breast cancer, agonist, estrogenic, apoptosis, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 60817.66

Authors

Fanning, S.W.,Rajan, S.S.,Maximov, P.Y.,Abderrahman, B.H.,Surojeet, S.,Fernandes, D.J.,Fan, P.,Curpan, R.F.,Greene, G.L.,Jordan, V.C. (deposition date: 2016-08-22, release date: 2017-08-30, Last modification date: 2023-10-04)

• Primary citation: Maximov, P.Y.,Abderrahman, B.,Fanning, S.W.,Sengupta, S.,Fan, P.,Curpan, R.F.,Rincon, D.M.Q.,Greenland, J.A.,Rajan, S.S.,Greene, G.L.,Jordan, V.C.; Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.; Mol. Pharmacol., 94:812-822, 2018; PubMed: 29739819; DOI: 10.1124/mol.117.111385

Experimental method

X-RAY DIFFRACTION (2.102 Å)