5SYS

c-Src V281C bound to N-[3-({6-[(1E)-2-cyano-3-(methylamino)-3-oxoprop-1-en-1-yl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor

Summary for 5SYS

• Entry DOI: 10.2210/pdb5sys/pdb
• Related: 5SWH
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-[3-({6-[(2S)-2-cyano-3-(methylamino)-3-oxopropyl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide (3 entities in total)
• Functional Keywords: dfg-out, covalently-linked inihibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66638.47

Authors

Dieter, E.M.,Merritt, E.A.,Maly, D.J. (deposition date: 2016-08-11, release date: 2017-08-16, Last modification date: 2023-10-04)

• Primary citation: Register, A.C.,Maly, D.J.; A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions; Mol.Cell, 2019:-,

Experimental method

X-RAY DIFFRACTION (2.8 Å)