5SXP
STRUCTURAL BASIS FOR THE INTERACTION BETWEEN ITCH PRR AND BETA-PIX
Summary for 5SXP
Entry DOI | 10.2210/pdb5sxp/pdb |
Descriptor | Rho guanine nucleotide exchange factor 7, E3 ubiquitin-protein ligase Itchy homolog (3 entities in total) |
Functional Keywords | sh3 domain peptide ligand complex, ligase, signaling protein-ligase complex, signaling protein/ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 34011.34 |
Authors | Cappadocia, L.,Desrochers, G.,Lussier-Price, M.,Angers, A.,Omichinski, J.G. (deposition date: 2016-08-09, release date: 2017-03-01, Last modification date: 2023-10-04) |
Primary citation | Desrochers, G.,Cappadocia, L.,Lussier-Price, M.,Ton, A.T.,Ayoubi, R.,Serohijos, A.,Omichinski, J.G.,Angers, A. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. J. Biol. Chem., 292:6325-6338, 2017 Cited by PubMed: 28235806DOI: 10.1074/jbc.M116.754440 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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