5SVF
IDH1 R132H in complex with IDH125
Summary for 5SVF
Entry DOI | 10.2210/pdb5svf/pdb |
Related | 5SUN 5SVN 5SVO |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, ... (5 entities in total) |
Functional Keywords | isocitrate dehydrogenase, rossmann fold, nadph, inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 4 |
Total formula weight | 192693.22 |
Authors | Xie, X.,Kulathila, R. (deposition date: 2016-08-05, release date: 2017-02-08, Last modification date: 2024-03-06) |
Primary citation | Xie, X.,Baird, D.,Bowen, K.,Capka, V.,Chen, J.,Chenail, G.,Cho, Y.,Dooley, J.,Farsidjani, A.,Fortin, P.,Kohls, D.,Kulathila, R.,Lin, F.,McKay, D.,Rodrigues, L.,Sage, D.,Toure, B.B.,van der Plas, S.,Wright, K.,Xu, M.,Yin, H.,Levell, J.,Pagliarini, R.A. Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25:506-513, 2017 Cited by PubMed: 28132785DOI: 10.1016/j.str.2016.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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