5SFE

Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-N,4-N,2-trimethylpyrazole-3,4-dicarboxamide

Summary for 5SFE

• Entry DOI: 10.2210/pdb5sfe/pdb
• Group deposition: Exploiting Structural Data for Improved On-Target Prediction in Lead Optimization (G_1002226)
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 159641.27

Authors

Joseph, C.,Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2022-01-21, release date: 2022-10-19, Last modification date: 2024-04-03)

• Primary citation: Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.86 Å)