5SB2

DDR1, 3-chloro-N-[(1R,2S)-2-phenylcyclopropyl]-5-(1H-pyrrolo[2,3-b]pyridin-5-yloxymethyl)benzamide, 1.600A, P212121, Rfree=23.2%

Summary for 5SB2

• Entry DOI: 10.2210/pdb5sb2/pdb
• Group deposition: Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
• Descriptor: Epithelial discoidin domain-containing receptor 1, IODIDE ION, 3-chloro-N-[(1R,2S)-2-phenylcyclopropyl]-5-{[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide, ... (4 entities in total)
• Functional Keywords: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37555.26

Authors

Stihle, M.,Richter, H.,Benz, J.,Kocer, B.,Hochstrasser, R.,Rudolph, M.G. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2024-04-03)

• Primary citation: Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a DDR1 complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)