5SAX

DDR1, 2-[3-(2-pyridin-3-ylethynyl)phenyl]-N-[3-(trifluoromethyl)phenyl]acetamide, 1.902A, second P212121 form, Rfree=25.4%, second form

Summary for 5SAX

• Entry DOI: 10.2210/pdb5sax/pdb
• Group deposition: Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
• Descriptor: Epithelial discoidin domain-containing receptor 1, IODIDE ION, 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-N-[3-(trifluoromethyl)phenyl]acetamide, ... (4 entities in total)
• Functional Keywords: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37898.45

Authors

Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2024-04-03)

• Primary citation: Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a DDR1 complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.902 Å)