5O9A

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution

Summary for 5O9A

Entry DOI	10.2210/pdb5o9a/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, SULFATE ION, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, ... (10 entities in total)
Functional Keywords	ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, signaling protein, ionotropic glutamate receptor, glua2, glur2, l504y-n775s
Biological source	Rattus norvegicus (Norway Rat) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P19491
Total number of polymer chains	4
Total formula weight	121368.12
Authors	Laulumaa, S.,Rovinskaja, K.,Frydenvang, K.A.,Kastrup, J.S. (deposition date: 2017-06-16, release date: 2018-01-03, Last modification date: 2024-01-17)
Primary citation	Goffin, E.,Drapier, T.,Larsen, A.P.,Geubelle, P.,Ptak, C.P.,Laulumaa, S.,Rovinskaja, K.,Gilissen, J.,Tullio, P.,Olsen, L.,Frydenvang, K.,Pirotte, B.,Hanson, J.,Oswald, R.E.,Kastrup, J.S.,Francotte, P. 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. J. Med. Chem., 61:251-264, 2018 Cited by PubMed: 29256599 DOI: 10.1021/acs.jmedchem.7b01323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation