5O7E
Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor
Summary for 5O7E
| Entry DOI | 10.2210/pdb5o7e/pdb |
| Related | 4arf |
| Descriptor | ColH protein, ZINC ION, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | hydrolase-inhibitor complex, gluzincin, metalloprotease, collagenase, hydrolase |
| Biological source | Hathewaya histolytica |
| Total number of polymer chains | 1 |
| Total formula weight | 46134.52 |
| Authors | Schoenauer, E.,Brandstetter, H. (deposition date: 2017-06-08, release date: 2018-01-31, Last modification date: 2024-01-17) |
| Primary citation | Schonauer, E.,Kany, A.M.,Haupenthal, J.,Husecken, K.,Hoppe, I.J.,Voos, K.,Yahiaoui, S.,Elsasser, B.,Ducho, C.,Brandstetter, H.,Hartmann, R.W. Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. J. Am. Chem. Soc., 139:12696-12703, 2017 Cited by PubMed: 28820255DOI: 10.1021/jacs.7b06935 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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