5O4F

Structure of GluK3 ligand-binding domain (S1S2) in complex with the agonist LM-12b at 2.10 A resolution

Summary for 5O4F

• Entry DOI: 10.2210/pdb5o4f/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 3, GLYCEROL, (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ... (7 entities in total)
• Functional Keywords: ionotropic glutamate receptor, kainate receptor, ligand-binding domain, gluk3, glur7, agonist, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P42264
• Total number of polymer chains: 2
• Total formula weight: 59700.52

Authors

Moellerud, S.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2017-05-29, release date: 2017-07-26, Last modification date: 2024-01-17)

• Primary citation: Mllerud, S.,Pinto, A.,Marconi, L.,Frydenvang, K.,Thorsen, T.S.,Laulumaa, S.,Venskutonyte, R.,Winther, S.,Moral, A.M.C.,Tamborini, L.,Conti, P.,Pickering, D.S.,Kastrup, J.S.; Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.; ACS Chem Neurosci, 8:2056-2064, 2017; PubMed: 28691798; DOI: 10.1021/acschemneuro.7b00201

Experimental method

X-RAY DIFFRACTION (2.1 Å)