5NU3

Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM-CBP

Summary for 5NU3

Entry DOI	10.2210/pdb5nu3/pdb
Descriptor	CREB-binding protein, ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, (R,R)-2,3-BUTANEDIOL, ... (5 entities in total)
Functional Keywords	bromodomain, protein-inhibitor complex, epigenetics, crebbp, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q92793
Total number of polymer chains	1
Total formula weight	15046.31
Authors	Huegle, M.,Wohlwend, D. (deposition date: 2017-04-28, release date: 2017-08-16, Last modification date: 2024-01-17)
Primary citation	Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D. Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017 Cited by PubMed: 28766825 DOI: 10.1002/anie.201705516 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation