5N68
Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9m
Summary for 5N68
Entry DOI | 10.2210/pdb5n68/pdb |
Descriptor | Mitogen-activated protein kinase 14, 2-(4-morpholin-4-ylphenyl)-~{N}4-(2-phenylethyl)quinazoline-4,7-diamine (3 entities in total) |
Functional Keywords | kinase, small molecule, lipid pocket, p38, quinazoline, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41768.72 |
Authors | Buehrmann, M.,Mueller, M.P.,Rauh, D. (deposition date: 2017-02-14, release date: 2017-09-20, Last modification date: 2024-01-17) |
Primary citation | Buhrmann, M.,Wiedemann, B.M.,Muller, M.P.,Hardick, J.,Ecke, M.,Rauh, D. Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38 alpha MAPK. PLoS ONE, 12:e0184627-e0184627, 2017 Cited by PubMed: 28892510DOI: 10.1371/journal.pone.0184627 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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