5N23

Protein kinase A mutants as surrogate model for Aurora B with AT9283 inhibitor

Summary for 5N23

• Entry DOI: 10.2210/pdb5n23/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, ... (4 entities in total)
• Functional Keywords: at9283, surrogate kinase, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm. Isoform 2: Cell projection, cilium, flagellum : P17612
• Total number of polymer chains: 2
• Total formula weight: 43641.40

Authors

Alam, K.A.,Rothweiler, U.,Engh, R.A. (deposition date: 2017-02-07, release date: 2018-03-14, Last modification date: 2024-01-17)

• Primary citation: Alam, K.A.,Engh, R.A.; Inhibitor induced structural effects involving Phe327 in AGC kinases; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.088 Å)