5N1Z
Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine macrocyclic ligand
Summary for 5N1Z
Entry DOI | 10.2210/pdb5n1z/pdb |
Descriptor | B-cell lymphoma 6 protein, CHLORIDE ION, pyrazolo-pyrimidine macrocycle, ... (4 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P41182 |
Total number of polymer chains | 1 |
Total formula weight | 14738.47 |
Authors | Robb, G.,Ferguson, A.,Hargreaves, D. (deposition date: 2017-02-06, release date: 2017-05-17, Last modification date: 2024-05-08) |
Primary citation | McCoull, W.,Abrams, R.D.,Anderson, E.,Blades, K.,Barton, P.,Box, M.,Burgess, J.,Byth, K.,Cao, Q.,Chuaqui, C.,Carbajo, R.J.,Cheung, T.,Code, E.,Ferguson, A.D.,Fillery, S.,Fuller, N.O.,Gangl, E.,Gao, N.,Grist, M.,Hargreaves, D.,Howard, M.R.,Hu, J.,Kemmitt, P.D.,Nelson, J.E.,O'Connell, N.,Prince, D.B.,Raubo, P.,Rawlins, P.B.,Robb, G.R.,Shi, J.,Waring, M.J.,Whittaker, D.,Wylot, M.,Zhu, X. Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J. Med. Chem., 60:4386-4402, 2017 Cited by PubMed: 28485934DOI: 10.1021/acs.jmedchem.7b00359 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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