5MYX
Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
Summary for 5MYX
Entry DOI | 10.2210/pdb5myx/pdb |
Descriptor | Fab c#24 light chain, Fab c#24 heavy chain, Pyroglutamate-Abeta pE3-18, ... (4 entities in total) |
Functional Keywords | alzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system |
Biological source | Mus musculus More |
Total number of polymer chains | 6 |
Total formula weight | 105330.25 |
Authors | Parthier, C.,Piechotta, A.,Stubbs, M.T. (deposition date: 2017-01-30, release date: 2017-06-28, Last modification date: 2024-01-17) |
Primary citation | Piechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T. Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292:12713-12724, 2017 Cited by PubMed: 28623233DOI: 10.1074/jbc.M117.777839 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.492 Å) |
Structure validation
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