5MWA

human sEH Phosphatase in complex with 3-4-3,4-dichlorophenyl-5-phenyl-1,3-oxazol-2-yl-benzoic-acid

Summary for 5MWA

Entry DOI	10.2210/pdb5mwa/pdb
Descriptor	Bifunctional epoxide hydrolase 2, MAGNESIUM ION, 3-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]benzoic acid, ... (4 entities in total)
Functional Keywords	phosphatase, complex, inhibitor, magnesium, human soluble epoxide hydrolase, seh, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	27835.41
Authors	Kramer, J.S.,Pogoryelov, D.,Sorrell, F.J.,Fox, N.,Chaikuad, A.,Knapp, S.,Proschak, E. (deposition date: 2017-01-18, release date: 2018-02-28, Last modification date: 2024-01-17)
Primary citation	Kramer, J.S.,Woltersdorf, S.,Duflot, T.,Hiesinger, K.,Lillich, F.F.,Knoll, F.,Wittmann, S.K.,Klingler, F.M.,Brunst, S.,Chaikuad, A.,Morisseau, C.,Hammock, B.D.,Buccellati, C.,Sala, A.,Rovati, G.E.,Leuillier, M.,Fraineau, S.,Rondeaux, J.,Hernandez Olmos, V.,Heering, J.,Merk, D.,Pogoryelov, D.,Steinhilber, D.,Knapp, S.,Bellien, J.,Proschak, E. Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. J.Med.Chem., 2019 Cited by PubMed: 31436984 DOI: 10.1021/acs.jmedchem.9b00445 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation