5MTS

Complex of FimH lectin with a TazMan (thiazolylaminomannosides) family member known as potent anti-adhesive agent at 2.6 A resolution

Summary for 5MTS

• Entry DOI: 10.2210/pdb5mts/pdb
• Descriptor: Protein FimH, [2-[[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]amino]-1,3-thiazol-5-yl]-(4-methyl-2-pyrazin-2-yl-1,3-thiazol-5-yl)methanone, NICKEL (II) ION, ... (4 entities in total)
• Functional Keywords: cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, crohn's disease
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 2
• Total formula weight: 64024.91

Authors

de Ruyck, J.,Bouckaert, J. (deposition date: 2017-01-10, release date: 2017-03-15, Last modification date: 2024-01-17)

• Primary citation: Alvarez Dorta, D.,Chalopin, T.,Sivignon, A.,de Ruyck, J.,Dumych, T.I.,Bilyy, R.O.,Deniaud, D.,Barnich, N.,Bouckaert, J.,Gouin, S.G.; Physiochemical Tuning of Potent Escherichia coli Anti-Adhesives by Microencapsulation and Methylene Homologation.; ChemMedChem, 12:986-998, 2017; PubMed: 28257558; DOI: 10.1002/cmdc.201700061

Experimental method

X-RAY DIFFRACTION (2.6 Å)